P-235: Ceftriaxone Effects on Sperm Quality and DNA Damage in Adult Mice

Background: Ceftriaxone is a third-generation Cephaloporin antibiotic. It has broad spectrum activity against gram-positive and gram-negative bacteria. There are some reports about its adverse effects on sperm quality and quantity but there is a need for more investigations so we did it. Materials and Methods: 40 adult male mice were divided into 3 groups as followings: a control group, high dose and low dose group receiving of saline normal, 20 mg/kg and 50 mg/kg Ceftriaxone respectively. Half of the treatment groups were analyzed after one week of daily injections and the other half after 45 days. Sperm quality factors such as total sperm count, sperm viability, DNA damage and percentage of immature sperms was evaluated. Results: Ceftriaxone reduced total sperm count and sperm viability in treatment groups and also increased percentage of immature sperms and sperms with DNA damage in treatment groups specially in high dose in comparison with the control group. Conclusion: These data revealed that Ceftriaxone can decrease sperm quality and quantity.